The jungle has a new nightmare.

When a remote Amazon expedition vanishes, elite survivalist Dr. Lena Reyes (Scarlett Johansson) and legendary river mercenary Jack Harlan (Chris Pratt) are sent deep into the uncharted Blood River — a cursed waterway stained red by an ancient, toxic bloom. What they discover is far worse than anything they imagined: a colossal new breed of Anaconda, mutated, hyper-aggressive, and growing larger with every kill.

Trapped on a crumbling research boat, hunted from both water and trees, the duo must fight for survival against the ᴅᴇᴀᴅliest snakes in history. With swarms of ᴅᴇᴀᴅly serpents, heart-stopping underwater attacks, and jaw-dropping chases through blood-red waters, every second is a fight for life.

Bigger. Meaner. Bloodier.

This time, the river runs red.