The series follows the Lioness program, an elite team of female operatives embedded in dangerous situations to gather intelligence and neutralize threats. At the center of the story is Joe, played by Zoe Saldaña, a seasoned CIA field officer who continues to navigate the dangerous waters of international espionage while managing the moral and personal challenges of leading her team.
The team must infiltrate dangerous environments, often going undercover in hostile territories where the line between ally and enemy is razor-thin.